Adaptive designs undertaken in clinical research: a review of registered clinical trials.

ABSTRACT: Adaptive designs have the potential to improve efficiency in the evaluation of new medical treatments in comparison to traditional fixed sample size designs. However, they are still not widely used in practice in clinical research. Little research has been conducted to investigate what adaptive designs are being undertaken. This review highlights the current state of registered adaptive designs and their characteristics. The review looked at phase II, II/III and III trials registered on ClinicalTrials.gov from 29 February 2000 to 1 June 2014, supplemented with trials from the National Institute for Health Research register and known adaptive trials. A range of adaptive design search terms were applied to the trials extracted from each database. Characteristics of the adaptive designs were

SUBMITTER: Hatfield I 

PROVIDER: S-EPMC4799596 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature