Randomized ICU trials do not demonstrate an association between interventions that reduce delirium duration and short-term mortality: a systematic review and meta-analysis.

ABSTRACT:

Objectives

We reviewed randomized trials of adult ICU patients of interventions hypothesized to reduce delirium burden to determine whether interventions that are more effective at reducing delirium duration are associated with a reduction in short-term mortality.

Data sources

We searched CINHAHL, EMBASE, MEDLINE, and the Cochrane databases from 2001 to 2012.

Study selection

Citations were screened for randomized trials that enrolled critically ill adults, evaluated delirium at least daily, compared a drug or nondrug intervention hypothesized to reduce delirium burden with standard care (or control), and reported delirium duration and/or short-term mortality (≤ 45 d).

Data extraction

In duplicate, we abstracted trial characteristics and results and evaluated qu

SUBMITTER: Al-Qadheeb NS 

PROVIDER: S-EPMC4799649 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature