Tumor microenvironment tenascin-C promotes glioblastoma invasion and negatively regulates tumor proliferation.

ABSTRACT:

Background

Glioblastoma (GBM) is the most frequent and aggressive primary brain tumor in adults. Recent research on cancer stroma indicates that the brain microenvironment plays a substantial role in tumor malignancy and treatment responses to current antitumor therapy. In this work, we have investigated the effect of alterations in brain tumor extracellular matrix tenascin-C (TNC) on brain tumor growth patterns including proliferation and invasion.

Methods

Since intracranial xenografts from patient-derived GBM neurospheres form highly invasive tumors that recapitulate the invasive features demonstrated in human patients diagnosed with GBM, we studied TNC gain-of-function and loss-of function in these GBM neurospheres in vitro and in vivo.

Results

TNC loss-of-function

SUBMITTER: Xia S 

PROVIDER: S-EPMC4799677 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature