Radiological features combined with IDH1 status for predicting the survival outcome of glioblastoma patients.

ABSTRACT:

Background

Radiological characteristics may reflect the biological features of brain tumors and may be associated with genetic alterations that occur in tumorigenesis. This study aimed to investigate the relationship between radiological features and IDH1 status as well as their predictive value for survival of glioblastoma patients.

Methods

The clinical information and MR images of 280 patients with histologically confirmed glioblastoma were retrospectively reviewed. The radiological characteristics of tumors were examined on MR images, and the IDH1 status was determined using DNA sequencing for all cases. The Kaplan-Meier method and Cox regression model were used to identify prognostic factors for progression-free and overall survival.

Results

The IDH1 mutation was

SUBMITTER: Wang K 

PROVIDER: S-EPMC4799681 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature