Pathology concordance levels for meningioma classification and grading in NRG Oncology RTOG Trial 0539.

ABSTRACT:

Background

With advances in the understanding of histopathology on outcome, accurate meningioma grading becomes critical and drives treatment selection. The 2000 and 2007 WHO schema greatly increased the proportion of grade II meningiomas. Although associations with progression-free survival (PFS) and overall survival (OS) have been independently validated, interobserver concordance has not been formally assessed.

Methods

Once mature, NRG Oncology RTOG-0539 will report PFS and OS in variably treated low-, intermediate-, and high-risk cohorts. We address concordance of histopathologic assessment between enrolling institutions and central review, performed by a single pathologist (AP), who is also involved in developing current WHO criteria.

Results

The trial included 1

SUBMITTER: Rogers CL 

PROVIDER: S-EPMC4799683 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature