Neuropathologic comorbidity and cognitive impairment in the Nun and Honolulu-Asia Aging Studies.

ABSTRACT:

Objective

To examine frequencies and relationships of 5 common neuropathologic abnormalities identified at autopsy with late-life cognitive impairment and dementia in 2 different autopsy panels.

Methods

The Nun Study (NS) and the Honolulu-Asia Aging Study (HAAS) are population-based investigations of brain aging that included repeated cognitive assessments and comprehensive brain autopsies. The neuropathologic abnormalities assessed were Alzheimer disease (AD) neuropathologic changes, neocortical Lewy bodies (LBs), hippocampal sclerosis, microinfarcts, and low brain weight. Associations with screening tests for cognitive impairment were examined.

Results

Neuropathologic abnormalities occurred at levels ranging from 9.7% to 43%, and were independently associated with c

SUBMITTER: White LR 

PROVIDER: S-EPMC4799714 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature