Longitudinal functional and NMR assessment of upper limbs in Duchenne muscular dystrophy.

ABSTRACT:

Objective

To explore the value of nuclear magnetic resonance (NMR) and functional assessments for follow-up of ambulatory and nonambulatory patients with Duchenne muscular dystrophy (DMD).

Methods

Twenty-five 53-skippable patients with DMD were included in this study; 15 were nonambulatory at baseline. All patients underwent clinical and functional assessments every 6 months using the Motor Function Measure (MFM), hand grip and key pinch strength, MoviPlate, and NMR spectroscopy and imaging studies.

Results

Upper limb distal strength decreased in nonambulatory patients over the period of 1 year; ambulatory patients showed improvement during the same period. The same applied for several NMRS indices, such as phosphocreatine/adenosine triphosphate, which decreased in ol

SUBMITTER: Hogrel JY 

PROVIDER: S-EPMC4799716 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature