Differential scanning calorimetry as a complementary diagnostic tool for the evaluation of biological samples.

ABSTRACT:

Background

Differential scanning calorimetry (DSC) is a tool for measuring the thermal stability profiles of complex molecular interactions in biological fluids. DSC profiles (thermograms) of biofluids provide specific signatures which are being utilized as a new diagnostic approach for characterizing disease but the development of these approaches is still in its infancy.

Methods

This article evaluates several approaches for the analysis of thermograms which could increase the utility of DSC for clinical application. Thermograms were analyzed using localized thermogram features and principal components (PCs). The performance of these methods was evaluated alongside six models for the classification of a data set comprised of 300 systemic lupus erythematosus (SLE) patients a

SUBMITTER: Garbett NC 

PROVIDER: S-EPMC4799750 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature