Monocytes promote liver carcinogenesis in an oncogene-specific manner.

ABSTRACT:

Background & aims

The leukocyte composition of tumors is heterogeneous, as is the involvement of each leukocyte subset in promoting or restraining tumorigenesis. This heterogeneity reflects the tissue of origin, tumor stage, and the functional state of leukocyte activation, but its biological roots remain poorly understood. Since tumorigenesis is driven by various genetic events, we assessed the role of driver genes in shaping the profiles and the roles of leukocytes in tumorigenesis.

Methods

Mouse liver tumors were induced by hepatic overexpression of either MYC or the combination of myristoylated AKT and NRAS(V12) oncogenes via hydrodynamic transfection. A comparative, flow cytometry- and histology-based immunophenotyping of liver-infiltrating leukocytes was performed at v

SUBMITTER: Juric V 

PROVIDER: S-EPMC4799762 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature