A novel approach for estimating ingested dose associated with paracetamol overdose.

ABSTRACT:

Aim

In cases of paracetamol (acetaminophen, APAP) overdose, an accurate estimate of tissue-specific paracetamol pharmacokinetics (PK) and ingested dose can offer health care providers important information for the individualized treatment and follow-up of affected patients. Here a novel methodology is presented to make such estimates using a standard serum paracetamol measurement and a computational framework.

Methods

The core component of the computational framework was a physiologically-based pharmacokinetic (PBPK) model developed and evaluated using an extensive set of human PK data. Bayesian inference was used for parameter and dose estimation, allowing the incorporation of inter-study variability, and facilitating the calculation of uncertainty in model outputs.

Resu

SUBMITTER: Zurlinden TJ 

PROVIDER: S-EPMC4799923 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature