Prognostic Value of SMAD4 in Pancreatic Cancer: A Meta-Analysis.

ABSTRACT:

Purpose

The prognostic value of SMAD4 in pancreatic cancer has been evaluated in several studies. However, the conclusions remain controversial. Therefore, we aimed to evaluate the association between SMAD4 expression and the outcome of pancreatic cancer patients by performing a meta-analysis.

Methods

We systematically searched for relevant studies evaluating the relationship between SMAD4 expression and the outcome of pancreatic cancer patients until May 2015. A meta-analysis was performed using STATA 12.0, and pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were used to estimate the strength of the association between SMAD4 expression and the prognosis of pancreatic cancer patients.

Results

The analysis included 1762 patients from 14 studies, with 140

SUBMITTER: Shugang X 

PROVIDER: S-EPMC4800056 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature