Development and Comparison of Warfarin Dosing Algorithms in Stroke Patients.

ABSTRACT:

Purpose

The genes for cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase complex subunit 1 (VKORC1) have been identified as important genetic determinants of warfarin dosing and have been studied. We developed warfarin algorithm for Korean patients with stroke and compared the accuracy of warfarin dose prediction algorithms based on the pharmacogenetics.

Materials and methods

A total of 101 patients on stable maintenance dose of warfarin were enrolled. Warfarin dosing algorithm was developed using multiple linear regression analysis. The performance of all the algorithms was characterized with coefficient of determination, determined by linear regression, and the mean of percent deviation was used to predict doses from the actual dose. In addition, we compared the

SUBMITTER: Cho SM 

PROVIDER: S-EPMC4800352 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature