Application of Whole-Genome Sequencing to an Unusual Outbreak of Invasive Group A Streptococcal Disease.

ABSTRACT: Whole-genome analysis was applied to investigate atypical point-source transmission of 2 invasive group A streptococcal (GAS) infections. Isolates were serotype M4, ST39, and genetically indistinguishable. Comparison with MGAS10750 revealed nonsynonymous polymorphisms in ropB and increased speB transcription. This study demonstrates the usefulness of whole-genome analyses for GAS outbreaks.

SUBMITTER: Galloway-Pena J 

PROVIDER: S-EPMC4800461 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature