Ontology highlight
ABSTRACT:
SUBMITTER: Walz AL
PROVIDER: S-EPMC4800737 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Cancer cell 20150201 2
We report the most common single-nucleotide substitution/deletion mutations in favorable histology Wilms tumors (FHWTs) to occur within SIX1/2 (7% of 534 tumors) and microRNA processing genes (miRNAPGs) DGCR8 and DROSHA (15% of 534 tumors). Comprehensive analysis of 77 FHWTs indicates that tumors with SIX1/2 and/or miRNAPG mutations show a pre-induction metanephric mesenchyme gene expression pattern and are significantly associated with both perilobar nephrogenic rests and 11p15 imprinting aberr ...[more]