Resting state connectivity of the medial prefrontal cortex covaries with individual differences in high-frequency heart rate variability.

ABSTRACT: Resting high-frequency heart rate variability (HF-HRV) relates to cardiac vagal control and predicts individual differences in health and longevity, but its functional neural correlates are not well defined. The medial prefrontal cortex (mPFC) encompasses visceral control regions that are components of intrinsic networks of the brain, particularly the default mode network (DMN) and the salience network (SN). Might individual differences in resting HF-HRV covary with resting state neural activity in the DMN and SN, particularly within the mPFC? This question was addressed using fMRI data from an eyes-open, 5-min rest period during which echoplanar brain imaging yielded BOLD time series. Independent component analysis yielded functional connectivity estimates defining the DMN and SN. HF-HRV

SUBMITTER: Jennings JR 

PROVIDER: S-EPMC4800828 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature