SrrAB Modulates Staphylococcus aureus Cell Death through Regulation of cidABC Transcription.

ABSTRACT:

Unlabelled

The death and lysis of a subpopulation in Staphylococcus aureus biofilm cells are thought to benefit the surviving population by releasing extracellular DNA, a critical component of the biofilm extracellular matrix. Although the means by which S. aureus controls cell death and lysis is not understood, studies implicate the role of the cidABC and lrgAB operons in this process. Recently, disruption of the srrAB regulatory locus was found to cause increased cell death during biofilm development, likely as a result of the sensitivity of this mutant to hypoxic growth. In the current study, we extended these findings by demonstrating that cell death in the ΔsrrAB mutant is dependent on expression of the cidABC operon. The effect of cidABC expression resulted in the generation

SUBMITTER: Windham IH 

PROVIDER: S-EPMC4800867 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature