COPD phenotypes on computed tomography and its correlation with selected lung function variables in severe patients.

ABSTRACT:

Background

Computed tomography (CT) phenotypic characterization helps in understanding the clinical diversity of chronic obstructive pulmonary disease (COPD) patients, but its clinical relevance and its relationship with functional features are not clarified. Volumetric capnography (VC) uses the principle of gas washout and analyzes the pattern of CO2 elimination as a function of expired volume. The main variables analyzed were end-tidal concentration of carbon dioxide (ETCO2), Slope of phase 2 (Slp2), and Slope of phase 3 (Slp3) of capnogram, the curve which represents the total amount of CO2 eliminated by the lungs during each breath.

Objective

To investigate, in a group of patients with severe COPD, if the phenotypic analysis by CT could identify different subsets of pati

SUBMITTER: da Silva SM 

PROVIDER: S-EPMC4801153 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature