Biopsychosocial influence on shoulder pain: risk subgroups translated across preclinical and clinical prospective cohorts.

ABSTRACT: Tailored treatment based on individual risk factors is an area with promise to improve options for pain relief. Musculoskeletal pain has a biopsychosocial nature, and multiple factors should be considered when determining risk for chronic pain. This study investigated whether subgroups comprised genetic and psychological factors predicted outcomes in preclinical and clinical models of shoulder pain. Classification and regression tree analysis was performed for an exercise-induced shoulder injury cohort (n = 190) to identify high-risk subgroups, and a surgical pain cohort (n = 150) was used for risk validation. Questionnaires for fear of pain and pain catastrophizing were administered before injury and preoperatively. DNA collected from saliva was genotyped for a priori selected genes invol

SUBMITTER: George SZ 

PROVIDER: S-EPMC4801181 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature