Characterization of choline transporters in the human placenta over gestation.

ABSTRACT:

Introduction

The developing fetus relies on the maternal blood supply to provide the choline it requires for making membrane lipids, synthesizing acetylcholine, and performing important methylation reactions. It is vital, therefore, that the placenta is efficient at transporting choline from the maternal to the fetal circulation. Although choline transporters have been found in term placenta samples, little is known about what cell types express specific choline transporters and how expression of the transporters may change over gestation. The objective of this study was to characterize choline transporter expression levels and localization in the human placenta throughout placental development.

Methods

We analyzed CTL1 and -2 expression over gestation in human placental bio

SUBMITTER: Baumgartner HK 

PROVIDER: S-EPMC4801320 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature