Association of atrial fibrillation risk alleles and response to acute rate control therapy.

ABSTRACT:

Objectives

Given the sparse evidence for selection of first-line therapy for acute atrial fibrillation (AF) based on clinical factors alone, incorporation of genotype data may improve the effectiveness of treatment algorithms and advance the understanding of interpatient heterogeneity. We tested whether candidate nucleotide polymorphisms (SNPs) related to AF physiologic responses are associated with ventricular rate control after intravenous diltiazem in the emergency department (ED).

Methods

We conducted an analysis within a prospective observational cohort of ED patients with acute symptomatic AF, ventricular rate >110 beats per minute within the first 2 hours, initially treated with intravenous diltiazem, and who had DNA available for analysis. We evaluated 24 candidate S

SUBMITTER: Barrett TW 

PROVIDER: S-EPMC4801711 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature