Microelectrode array stimulation combined with intrinsic optical imaging: A novel tool for functional brain mapping.

ABSTRACT:

Background

Functional brain mapping via cortical microstimulation is a widely used clinical and experimental tool. However, data are traditionally collected point by point, making the technique very time consuming. Moreover, even in skilled hands, consistent penetration depths are difficult to achieve. Finally, the effects of microstimulation are assessed behaviorally, with no attempt to capture the activity of the local cortical circuits being stimulated.

New method

We propose a novel method for functional brain mapping, which combines the use of a microelectrode array with intrinsic optical imaging. The precise spacing of electrodes allows for fast, accurate mapping of the area of interest in a regular grid. At the same time, the optical window allows for visualization of

SUBMITTER: Chernov MM 

PROVIDER: S-EPMC4801717 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature