The impact of treatment condition and the lagged effects of PTSD symptom severity and alcohol use on changes in alcohol craving.

ABSTRACT: Given the high rates of comorbidity between posttraumatic stress disorder (PTSD) and substance use disorder (SUD), we investigated an integrated treatment for these disorders. Individuals with comorbid PTSD and alcohol dependence were randomized to receive naltrexone or placebo, with or without prolonged exposure (PE). All participants also received BRENDA (supportive counseling). The naltrexone plus PE group showed a greater decline in alcohol craving symptoms than those in the placebo with no PE group. The PE plus placebo and the naltrexone without PE groups did not differ significantly from the placebo with no PE group in terms of alcohol craving. No treatment group differences were found for percentage of drinking days. Alcohol craving was moderated by PTSD severity, with those with hi

SUBMITTER: Kaczkurkin AN 

PROVIDER: S-EPMC4801783 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature