Ontology highlight
ABSTRACT:
SUBMITTER: Ji Q
PROVIDER: S-EPMC4802049 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Nature communications 20160318
Most low GC Gram-positive bacteria possess an essential walKR two-component system (TCS) for signal transduction involved in regulating cell wall homoeostasis. Despite the well-established intracellular regulatory mechanism, the role of this TCS in extracellular signal recognition and factors that modulate the activity of this TCS remain largely unknown. Here we identify the extracellular receptor of the kinase 'WalK' (erWalK) as a key hub for bridging extracellular signal input and intracellula ...[more]