A strategy for sequence control in vinyl polymers via iterative controlled radical cyclization.

ABSTRACT: There is a growing interest in sequence-controlled polymers toward advanced functional materials. However, control of side-chain order for vinyl polymers has been lacking feasibility in the field of polymer synthesis because of the inherent feature of chain-growth propagation. Here we show a general and versatile strategy to control sequence in vinyl polymers through iterative radical cyclization with orthogonally cleavable and renewable bonds. The proposed methodology employs a repetitive and iterative intramolecular cyclization via a radical intermediate in a one-time template with a radical-generating site at one end and an alkene end at the other, each of which is connected to a linker via independently cleavable and renewable bonds. The unique design specifically allowed control of ra

SUBMITTER: Hibi Y 

PROVIDER: S-EPMC4802161 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature