Ontology highlight
ABSTRACT:
SUBMITTER: Byrne KM
PROVIDER: S-EPMC4802415 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Cell systems 20160127 1
Dynamic interactions between RhoA and Rac1, members of the Rho small GTPase family, play a vital role in the control of cell migration. Using predictive mathematical modeling, mass spectrometry-based quantitation of network components, and experimental validation in MDA-MB-231 mesenchymal breast cancer cells, we show that a network containing Rac1, RhoA, and PAK family kinases can produce bistable, switch-like responses to a graded PAK inhibition. Using a small chemical inhibitor of PAK, we demo ...[more]