A Composite Gene Expression Signature Optimizes Prediction of Colorectal Cancer Metastasis and Outcome.

ABSTRACT:

Purpose

We previously found that an epithelial-to-mesenchymal transition (EMT)-based gene expression signature was highly correlated with the first principal component (PC1) of 326 colorectal cancer tumors and was prognostic. This study was designed to improve these signatures for better prediction of metastasis and outcome.

Experimental design

A total of 468 colorectal cancer tumors including all stages (I-IV) and metastatic lesions were used to develop a new prognostic score (ΔPC1.EMT) by subtracting the EMT signature score from its correlated PC1 signature score. The score was validated on six other independent datasets with a total of 3,697 tumors.

Results

ΔPC1.EMT was found to be far more predictive of metastasis and outcome than its parent scores. It performed w

SUBMITTER: Schell MJ 

PROVIDER: S-EPMC4802496 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature