Ontology highlight
ABSTRACT:
SUBMITTER: Gabelli SB
PROVIDER: S-EPMC4802738 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Gabelli Sandra B SB Yoder Jesse B JB Tomaselli Gordon F GF Amzel L Mario LM
Channels (Austin, Tex.) 20150728 1
The structures of the cytosolic portion of voltage activated sodium channels (CTNav) in complexes with calmodulin and other effectors in the presence and the absence of calcium provide information about the mechanisms by which these effectors regulate channel activity. The most studied of these complexes, those of Nav1.2 and Nav1.5, show details of the conformations and the specific contacts that are involved in channel regulation. Another voltage activated sodium channel, Nav1.4, shows signific ...[more]