Circulating biologically active oxidized phospholipids show on-going and increased oxidative stress in older male mice.

ABSTRACT:

Background

The biologically active phospholipids Platelet-activating Factor (PAF) and oxidatively truncated phospholipids from chemical oxidation are increased in the circulation of rats subject to the oxidant stress of chronic ethanol ingestion. Potentially, circulating inflammatory and apoptotic phospholipids correlate to physiologic oxidative stress.

Results

PAF and the common oxidatively truncated and biologically active phospholipid azelaoyl phosphatidylcholine (Az-PC) were significantly increased in the plasma of older mice, and in male mice. PAF and Az-PC are very rapidly cleared from the circulation, which was unaffected by age or sex. Platelets exposed to Az-PC display phosphatidylserine on their surface, and occlusive platelet carotid arterial thrombosis is enhance

SUBMITTER: Liu J 

PROVIDER: S-EPMC4802831 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature