Effect of propofol and sevoflurane on the inflammatory response of patients undergoing craniotomy.

ABSTRACT:

Background

The purpose of this randomised, single-centre study was to prospectively investigate the impact of anaesthetic techniques for craniotomy on the release of cytokines IL-6, IL-8, IL-10, and to determine whether intravenous anaesthesia compared to inhalational anaesthesia attenuates the inflammatory response.

Methods

The study enroled 40 patients undergoing craniotomy, allocated into two equal groups to receive either sevoflurane (n = 20) or propofol (n = 20) in conjunction with remifentanil and rocuronium. The lungs were ventilated mechanically to maintain normocapnia. Remifentanil infusion was adjusted according to the degree of surgical manipulation and increased when mean arterial pressure and the heart rate increased by more than 30 % from baseline. The depth of

SUBMITTER: Markovic-Bozic J 

PROVIDER: S-EPMC4802874 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature