Subthalamic nucleus phase-amplitude coupling correlates with motor impairment in Parkinson's disease.

ABSTRACT:

Objective

High-amplitude beta band oscillations within the subthalamic nucleus are frequently associated with Parkinson's disease but it is unclear how they might lead to motor impairments. Here we investigate a likely pathological coupling between the phase of beta band oscillations and the amplitude of high-frequency oscillations around 300 Hz.

Methods

We analysed an extensive data set comprising resting-state recordings obtained from deep brain stimulation electrodes in 33 patients before and/or after taking dopaminergic medication. We correlated mean values of spectral power and phase-amplitude coupling with severity of hemibody bradykinesia/rigidity. In addition, we used simultaneously recorded magnetoencephalography to look at functional interactions between the subtha

SUBMITTER: van Wijk BC 

PROVIDER: S-EPMC4803022 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature