Systems genetics of intravenous cocaine self-administration in the BXD recombinant inbred mouse panel.

ABSTRACT:

Rationale

Cocaine addiction is a major public health problem with a substantial genetic basis for which the biological mechanisms remain largely unknown. Systems genetics is a powerful method for discovering novel mechanisms underlying complex traits, and intravenous drug self-administration (IVSA) is the gold standard for assessing volitional drug use in preclinical studies. We have integrated these approaches to identify novel genes and networks underlying cocaine use in mice.

Methods

Mice from 39 BXD strains acquired cocaine IVSA (0.56 mg/kg/infusion). Mice from 29 BXD strains completed a full dose-response curve (0.032-1.8 mg/kg/infusion). We identified independent genetic correlations between cocaine IVSA and measures of environmental exploration and cocaine sensitizati

SUBMITTER: Dickson PE 

PROVIDER: S-EPMC4803082 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature