Influence of Postprandial Hyperglycemic Conditions on Arterial Stiffness in Patients With Type 2 Diabetes.

ABSTRACT:

Context

Patients with type 2 diabetes (T2D) are at an increased risk of cardiovascular disease.

Objective

The objective of the study was to determine whether postprandial hyperglycemia affects arterial function in T2D.

Design

A single-center, open-label study of three groups of men were studied: 1) T2D patients with albuminuria (n = 22), 2) T2D patients without albuminuria (n = 24), and 3) nondiabetic controls (n = 25). Patients were randomized to a two-period crossover study schedule, ingesting breakfast, with or without insulin lispro (to induce low or high postprandial glycemia).

Main outcome measures

Arterial stiffness was assessed by calculating pulse wave velocity (PWV) and augmentation index using applanation tonometry, and endothelial dysfunction was as

SUBMITTER: Gordin D 

PROVIDER: S-EPMC4803174 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature