The HABP2 G534E variant is an unlikely cause of familial non-medullary thyroid cancer.

ABSTRACT:

Context

A recent study reported the non-synonymous G534E (rs7080536, allele A) variant in the HABP2 gene as causal in familial non-medullary thyroid cancer (NMTC).

Objective

The objective of this study was to evaluate the causality of HABP2 G534E in the TCUKIN study, a multi-center population based study of NMTC cases from the British Isles.

Design and setting

A case-control analysis of rs7080536 genotypes was performed using 2,105 TCUKIN cases and 5,172 UK controls.

Participants

Cases comprised 2,105 NMTC cases. Patients sub-groups with papillary (N=1,056), follicular (N=691) and Hurthle cell (N=86) TC cases were studied separately. Controls comprised 5,172 individuals from the 1958 Birth Cohort (58C) and the National Blood Donor Service (NBS) study. The contr

SUBMITTER: Sahasrabudhe R 

PROVIDER: S-EPMC4803181 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature