The Preferred Directions of Conjunctive Grid X Head Direction Cells in the Medial Entorhinal Cortex Are Periodically Organized.

ABSTRACT: The discovery of speed-modulated grid, head direction, and conjunctive grid x head direction cells in the medial entorhinal cortex has led to the hypothesis that path integration, the updating of one's spatial representation based on movement, may be carried out within this region. This hypothesis has been formalized by many computational models, including a class known as attractor network models. While many of these models propose specific mechanisms by which path integration might occur, predictions of these specific mechanisms have not been tested. Here I derive and test a key prediction of one attractor network path integration mechanism. Specifically, I first demonstrate that this mechanism predicts a periodic distribution of conjunctive cell preferred directions in order to minimize

SUBMITTER: Keinath AT 

PROVIDER: S-EPMC4803195 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature