Measurement of Myocardial T1ρ with a Motion Corrected, Parametric Mapping Sequence in Humans.

ABSTRACT:

Purpose

To develop a robust T1ρ magnetic resonance imaging (MRI) sequence for assessment of myocardial disease in humans.

Materials and methods

We developed a breath-held T1ρ mapping method using a single-shot, T1ρ-prepared balanced steady-state free-precession (bSSFP) sequence. The magnetization trajectory was simulated to identify sources of T1ρ error. To limit motion artifacts, an optical flow-based image registration method was used to align T1ρ images. The reproducibility and accuracy of these methods was assessed in phantoms and 10 healthy subjects. Results are shown in 1 patient with pre-ventricular contractions (PVCs), 1 patient with chronic myocardial infarction (MI) and 2 patients with hypertrophic cardiomyopathy (HCM).

Results

In phantoms, the mean bias was

SUBMITTER: Berisha S 

PROVIDER: S-EPMC4803208 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature