Association of Peak Changes in Plasma Cystatin C and Creatinine With Death After Cardiac Operations.

ABSTRACT:

Background

Acute kidney injury is a risk factor for death in cardiac surgical patients. Plasma cystatin C and creatinine have different temporal profiles in the postoperative setting, but the associations of simultaneous changes in both filtration markers compared with change in only one marker with prognosis after hospital discharge are not well described.

Methods

This is a longitudinal study of 1,199 high-risk adult cardiac surgical patients in the TRIBE-AKI (Translational Research Investigating Biomarker Endpoints for Acute Kidney Injury) Consortium who survived hospitalization. We examined in-hospital peak changes of cystatin C and creatinine in the 3 days after cardiac operations. We evaluated associations of these filtration markers with death, adjusting for demographi

SUBMITTER: Park M 

PROVIDER: S-EPMC4803601 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature