Race-Specific Influence of CYP4F2 on Dose and Risk of Hemorrhage Among Warfarin Users.

ABSTRACT:

Objective

The p.V433M in cytochrome P450 4F2 (rs2108622, CYP4F2*3) is associated with a higher warfarin dose and lower risk of hemorrhage among European Americans. We evaluate the influence of CYP4F2*3 on warfarin dose, time to target international normalized ratio (INR), and stable dose, proportion of time spent in target range (PTTR), as well as the risk of overanticoagulation and hemorrhage among European and African Americans.

Design

CYP4F2*3 was genotyped in 1238 patients initiated on warfarin in a prospective inception cohort. Multivariable linear regression was used to assess warfarin dose and PTTR; proportional hazards analysis was performed to evaluate time to target INR and stable dose, overanticoagulation, and hemorrhage.

Setting

Two outpatient anticoagulat

SUBMITTER: Shendre A 

PROVIDER: S-EPMC4803610 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature