Effects of salience-network-node neurofeedback training on affective biases in major depressive disorder.

ABSTRACT: Neural models of major depressive disorder (MDD) posit that over-response of components of the brain's salience network (SN) to negative stimuli plays a crucial role in the pathophysiology of MDD. In the present proof-of-concept study, we tested this formulation directly by examining the affective consequences of training depressed persons to down-regulate response of SN nodes to negative material. Ten participants in the real neurofeedback group saw, and attempted to learn to down-regulate, activity from an empirically identified node of the SN. Ten other participants engaged in an equivalent procedure with the exception that they saw SN-node neurofeedback indices from participants in the real neurofeedback group. Before and after scanning, all participants completed tasks assessing emoti

SUBMITTER: Hamilton JP 

PROVIDER: S-EPMC4803612 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature