DISC1 as a Possible Genetic Contribution to Opioid Dependence in a Polish Sample.

ABSTRACT:

Objective

Disrupted-in-schizophrenia 1 (DISC1) has been linked to vulnerability to a variety of psychiatric disorders and neuropsychiatric phenotypes. However, DISC1 has not been frequently examined as a potential risk factor for substance dependence. An association between opioid dependence and DISC1 rs2738888 polymorphism has been recently reported. In addition, opioid dependence was associated with rs6419156 located close to the protein phosphatase 3 catalytic subunit alpha isoform (PPP3CA) gene. The aim of the present study was to examine the associations between opioid dependence with rs2738888 and rs6419156 in an independent sample.

Method

The selected polymorphisms were genotyped in a sample of 392 individuals (69.9% male) diagnosed as alcohol- and/or opioid-dependent

SUBMITTER: Fudalej S 

PROVIDER: S-EPMC4803654 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature