The impact of an interventional counselling procedure in families with a BRCA1/2 gene mutation: efficacy and safety.

ABSTRACT:

Background

Predictive genetic testing has high impact on cancer prevention for BRCA carriers and passing this information in BRCA families is important. Mostly, this is proband-mediated but this path is defective and denies relatives lifesaving information.

Objective

To assess the efficacy/safety of an intervention, in which relatives are actively informed.

Design

Sequential prospective study in new BRCA families. The proband informed relatives about predictive testing (phase I). After 6 months, a letter was sent to adult relatives who had not been reached (phase II). Then a phone call was made to obtain a final notion of their wishes. All subjects received psychometric testing (State-Trait Anxiety Inventory, STAI), an interview and routine counselling.

Results

SUBMITTER: Sermijn E 

PROVIDER: S-EPMC4803813 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature