Semiparametric regression for the weighted composite endpoint of recurrent and terminal events.

ABSTRACT: Recurrent event data are commonly encountered in clinical and epidemiological studies. A major complication arises when recurrent events are terminated by death. To assess the overall effects of covariates on the two types of events, we define a weighted composite endpoint as the cumulative number of recurrent and terminal events properly weighted by the relative severity of each event. We propose a semiparametric proportional rates model which specifies that the (possibly time-varying) covariates have multiplicative effects on the rate function of the weighted composite endpoint while leaving the form of the rate function and the dependence among recurrent and terminal events completely unspecified. We construct appropriate estimators for the regression parameters and the cumulative frequ

SUBMITTER: Mao L 

PROVIDER: S-EPMC4804115 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature