Antidepressant use and risk of cardiovascular outcomes in people aged 20 to 64: cohort study using primary care database.

ABSTRACT:

Objective

To assess associations between different antidepressant treatments and rates of three cardiovascular outcomes (myocardial infarction, stroke or transient ischaemic attack, and arrhythmia) in people with depression.

Design

Cohort study.

Setting

UK general practices contributing to the QResearch primary care database.

Participants

238,963 patients aged 20 to 64 years with a first diagnosis of depression between 1 January 2000 and 31 July 2011.

Exposures

Antidepressant class (tricyclic and related antidepressants, selective serotonin reuptake inhibitors, other antidepressants), dose, duration of use, and commonly prescribed individual antidepressant drugs.

Main outcome measures

First diagnoses of myocardial infarction, stroke or transient i

SUBMITTER: Coupland C 

PROVIDER: S-EPMC4804126 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature