Changing pattern in the basal ganglia: motor switching under reduced dopaminergic drive.

ABSTRACT: Action selection in the basal ganglia is often described within the framework of a standard model, associating low dopaminergic drive with motor suppression. Whilst powerful, this model does not explain several clinical and experimental data, including varying therapeutic efficacy across movement disorders. We tested the predictions of this model in patients with Parkinson's disease, on and off subthalamic deep brain stimulation (DBS), focussing on adaptive sensory-motor responses to a changing environment and maintenance of an action until it is no longer suitable. Surprisingly, we observed prolonged perseverance under on-stimulation, and high inter-individual variability in terms of the motor selections performed when comparing the two conditions. To account for these data, we revised th

SUBMITTER: Fiore VG 

PROVIDER: S-EPMC4804216 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature