Impact of structure space continuity on protein fold classification.

ABSTRACT: Protein structure classification hierarchically clusters domain structures based on structure and/or sequence similarities and plays important roles in the study of protein structure-function relationship and protein evolution. Among many classifications, SCOP and CATH are widely viewed as the gold standards. Fold classification is of special interest because this is the lowest level of classification that does not depend on protein sequence similarity. The current fold classifications such as those in SCOP and CATH are controversial because they implicitly assume that folds are discrete islands in the structure space, whereas increasing evidence suggests significant similarities among folds and supports a continuous fold space. Although this problem is widely recognized, its impact on fol

SUBMITTER: Xu J 

PROVIDER: S-EPMC4804218 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature