Interpreting whole genome sequencing for investigating tuberculosis transmission: a systematic review.

ABSTRACT:

Background

Whole genome sequencing (WGS) is becoming an important part of epidemiological investigations of infectious diseases due to greater resolution and cost reductions compared to traditional typing approaches. Many public health and clinical teams will increasingly use WGS to investigate clusters of potential pathogen transmission, making it crucial to understand the benefits and assumptions of the analytical methods for investigating the data. We aimed to understand how different approaches affect inferences of transmission dynamics and outline limitations of the methods.

Methods

We comprehensively searched electronic databases for studies that presented methods used to interpret WGS data for investigating tuberculosis (TB) transmission. Two authors independently sel

SUBMITTER: Hatherell HA 

PROVIDER: S-EPMC4804562 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature