Factors associated with serum fetuin-A concentrations after long-term use of different phosphate binders in hemodialysis patients.

ABSTRACT:

Background

Fetuin-A is known as a circulating inhibitor of vascular calcification. Factors associated with serum fetuin-A concentrations after long-term use of different phosphate binders in hemodialysis patients is still uncertain.

Methods

In the post-hoc study, we analyzed serum fetuin-A and biochemical factors (Ca, P, i-PTH, hsCRP, TG, LDL-C) in 50 hemodialysis patients, who completed a 48-week, open-Label, controlled randomized parallel-group study. 23 patients received sevelamer and 27 patients received calcium carbonate.

Results

After the 48-week treatment, the sevelamer group had less serum calcium increment, less iPTH decrement, more ALK-P increment, more hsCRP decrement and more LDL-C decrement. There was no significant difference in the serum fetuin-A decrem

SUBMITTER: Lin HH 

PROVIDER: S-EPMC4804565 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature