Ig Superfamily Ligand and Receptor Pairs Expressed in Synaptic Partners in Drosophila.

ABSTRACT: Information processing relies on precise patterns of synapses between neurons. The cellular recognition mechanisms regulating this specificity are poorly understood. In the medulla of the Drosophila visual system, different neurons form synaptic connections in different layers. Here, we sought to identify candidate cell recognition molecules underlying this specificity. Using RNA sequencing (RNA-seq), we show that neurons with different synaptic specificities express unique combinations of mRNAs encoding hundreds of cell surface and secreted proteins. Using RNA-seq and protein tagging, we demonstrate that 21 paralogs of the Dpr family, a subclass of immunoglobulin (Ig)-domain containing proteins, are expressed in unique combinations in homologous neurons with different layer-specific synap

SUBMITTER: Tan L 

PROVIDER: S-EPMC4804707 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature