Integrating full spectrum of sequence features into predicting functional microRNA-mRNA interactions.

ABSTRACT:

Motivation

MicroRNAs (miRNAs) play important roles in general biological processes and diseases pathogenesis. Identifying miRNA target genes is an essential step to fully understand the regulatory effects of miRNAs. Many computational methods based on the sequence complementary rules and the miRNA and mRNA expression profiles have been developed for this purpose. It is noted that there have been many sequence features of miRNA targets available, including the context features of the target sites, the thermodynamic stability and the accessibility energy for miRNA-mRNA interaction. However, most of current computational methods that combine sequence and expression information do not effectively integrate full spectrum of these features; instead, they perceive putative miRNA-mRNA inte

SUBMITTER: Wang Z 

PROVIDER: S-EPMC4804770 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature