Batf3 and Id2 have a synergistic effect on Irf8-directed classical CD8α+ dendritic cell development.

ABSTRACT: Dendritic cells (DCs) are heterogeneous cell populations represented by different subtypes, each varying in terms of gene expression patterns and specific functions. Recent studies identified transcription factors essential for the development of different DC subtypes, yet molecular mechanisms for the developmental program and functions remain poorly understood. In this study, we developed and characterized a mouse DC progenitor-like cell line, designated DC9, from Irf8(-/-) bone marrow cells as a model for DC development and function. Expression of Irf8 in DC9 cells led to plasmacytoid DCs and CD8α(+) DC-like cells, with a concomitant increase in plasmacytoid DC- and CD8α(+) DC-specific gene transcripts and induction of type I IFNs and IL12p40 following TLR ligand stimulation. Irf8 expres

SUBMITTER: Jaiswal H 

PROVIDER: S-EPMC4805111 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature