APOL1 nephropathy risk variants are associated with altered high-density lipoprotein profiles in African Americans.

ABSTRACT:

Background

Two independent coding variants in the apolipoprotein L1 gene (APOL1), G1 and G2, strongly associate with nephropathy in African Americans; associations with cardiovascular disease are more controversial. Although APOL1 binds plasma high-density lipoproteins (HDLs), data on APOL1 risk variant associations with HDL subfractions are sparse.

Methods

Two APOL1 G1 single nucleotide polymorphisms and the G2 insertion/deletion polymorphism were genotyped in 2010 Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study participants with nuclear magnetic resonance spectroscopy-based lipoprotein subfraction measurements. Linear regression was used to model associations between numbers of APOL1 G1/G2 risk variants and HDL subfractions, adjusting for demographi

SUBMITTER: Gutierrez OM 

PROVIDER: S-EPMC4805128 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature